Scientists at the and the have found a new way to inhibit the growth of the bacterium that causes tuberculosis (TB).
Â鶹´«Ã½Ó³» Deputy Head said the discovery held promise for the development of treatments.
The research team, led by in the US, investigated the impact of compounds related to cholesterol on the tuberculosis-causing bacterium Mycobacterium tuberculosis. Cholesterol is known to affect the virulence and infectivity of TB.
“What Paul’s team and our team have shown is that if you give this bacterium modified cholesterol instead, then it can’t use it as its energy source and so it stops growing, “Professor De Voss said.
“Interestingly, we don’t quite understand why this happens.
“Our discovery suggests a new way in which we can robustly inhibit growth of the TB bacterium.”
TB is a highly infectious lung disease that kills one person every 21 seconds.
There were 9.6 million new cases of TB in 2014, resulting in 1.5 million deaths.
One in three people globally is infected with TB, with the bulk of the disease burden falling on developing countries.
Professor De Voss said the scale of the threat, compounded by the emergence of increasingly drug-resistant strains of bacteria, meant it was vital to find new ways to combat tuberculosis.
The team at Â鶹´«Ã½Ó³», including postdoctoral research fellow , was responsible for synthesising inhibitors of the enzymes used to modify the cholesterol by M. tuberculosis.
The research was funded by the National Institutes of Health and is published in the .
Professor De Voss said his team would now partner with School of Chemistry and Molecular Biosciences researcher , who is the founder and Laboratory Head of the Â鶹´«Ã½Ó³» Tuberculosis Research Laboratory, the only Australian laboratory dedicated to TB microbiology.
Media: Professor James De Voss, j.devoss@uq.edu.au, +61 7 3365 3825; Dr Siew Hoon Wong, s.wong9@uq.edu.au, +61 7 3365 3686.
