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Spiders have helped researchers from Australia and the US discover a new target for irritable bowel syndrome pain.

The international research team – involving researchers from Â鶹´«Ã½Ó³»­ of Queensland (Â鶹´«Ã½Ó³»­) and the – used spider venom to identify a specific protein involved in transmitting mechanical pain, which is the type of pain experienced by patients with irritable bowel syndrome.

Â鶹´«Ã½Ó³»­ Institute for Molecular Bioscience (IMB) researcher Professor Glenn King said the discovery was a vital step forward in developing treatments.

“Spider venom is an effective tool for investigating pain signalling in the human body,” he said.

“Spiders make toxins to kill prey and defend themselves against predators, and the most effective way to defend against a predator is to make them feel excruciating pain.

“Spider venom should therefore be full of molecules that stimulate the pain-sensing nerves in our body, allowing us to discover new pain pathways by examining which nerves are activated when exposed to spider toxins.”

The team found that an ion channel (a protein in nerves and muscles) called Na_V1.1, previously implicated in epilepsy, was activated by the spider venom, suggesting it also played a significant role in sensing and transmitting pain.

Further investigation revealed that Na_V1.1 was present in pain-sensing nerves in the gut and underlies pathological levels of abdominal pain, such as that felt by irritable bowel syndrome patients.

Associate Professor Brierley, currently at the and soon to be a Matthew Flinders Fellow at , said one in five Australians suffered from irritable bowel syndrome, with symptoms including abdominal pain, diarrhoea and constipation.

“Irritable bowel syndrome places a large burden on individuals and on the health system, but there are currently no effective treatments,” Associate Professor Brierley said.

“Instead, sufferers are advised to avoid triggers that will cause their symptoms to flare up.

“Identifying the crucial role Na_V1.1 makes in signalling of chronic pain is the first step in developing novel treatments.”

The team is now developing molecules that will block Na_V1.1 and alleviate irritable bowel syndrome pain.

The research team is led by Professor King, Associate Professor Brierley, who is based at the (SAHMRI), Professor David Julius from the , and Dr Frank Bosmans from .

The research, published today in the journal , was supported by the .

Media: IMB Communications, communications@imb.uq.edu.au, 07 3346 2134, 0416 273 279; University of Adelaide Media and Communications Officer David Ellis, david.ellis@adelaide.edu.au, 08 8313 5414, 0421 612 762; SAHMRI Marketing and Media Manager Bridgette Whittle, bridgette.whittle@sahmri.com, 08 8128 4153, 0434 072 866.